Is the unresponsiveness to sumatriptan in cluster headache related to an alteration in the 5-HT receptors?
Int J
Clin Pharmacol Res. 1993;13(5):247-53.
Stirparo G, Fusco BM, Giacovazzo M, Rinaldi C, Martelletti P
Institute of Biomedical Technologies, CNR, Rome, Italy.
It is well established that cluster headache shows impaired functions
at the neuroimmunomodulatory system level. Defects in the expression of
receptors for 5-HT, IL-1 and IL-2 have been found in these patients.
Sumatriptan, an agonist activity for 5-HT1D receptor, truncates cluster
headache attack in 74% of patients. Flow cytometric analysis of
monocytes expressing 5-HT receptor in cluster headache patients showed
different trends clearly correlated with the clinical response to
sumatriptan. Our findings strongly support the concept that cluster
headache patients which are non-responders to sumatriptan could present
a block in their 5-HT receptor expression possibly due to specific
autoantibodies for this receptor site.
PMID: 7515379Entrez PubMed
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