| The medications on this page are some of the more common ones prescribed to treat cluster headaches. This list is made available strictly for you to have options to discuss with your physician. Do not take any medicine or nutritional supplement for your headaches without discussing it with your physician first! |
Cluster Headache Medications
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Cluster Headache medications are divided into three main classes: Abortive - designed to quickly stop an individual attack; Preventative - to eliminate attacks all together or to minimize them so a sufferer can lead as close to a normal life as possible; and Transitional - designed to temporarily stop attacks until a long term preventative can take effect. |
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Abortive Medications |
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| Name | Type of Drug | Composition | Comments | |
| Imitrex | vasoconstrictor | sumatriptan succinate | Comes in tablet, nasal and injectible forms. If you don't like needles click here for a needleless injector. | |
| Amerge | vasoconstrictor | naratriptan hydrocloride | 1mg and 2.5mg tablets | |
| Please visit the medication survey page at www.clusterheadaches.com to enter your personal experiences with medications and to view other's success with them. This is a great resource in helping decide which medications work best for cluster headaches. | Zomig | vasoconstrictor | zolmitriptan | 2.5mg and 5mg tablets; 5mg nasal spray |
| Axert | vasoconstrictor | almotriptan malate | 6.25mg and 12.5mg tablets | |
| Oxygen | vasoconstrictor | oxygen | 7 to 15 liters/minute via a non-rebreathing mask for 10 to 20 minutes | |
| Click here for a comparison of all the triptan based medications. | ||||
| Cafergot / Ercaf / ergotamine | vasoconstrictor | ergotamine | Tablets / suppositories / sublingual tablets | |
| Get all the dope (pun intended) on your medications. Visit RXList.com to search for info on your medications. | Dihydroergotamine (DHE 45) |
vasoconstrictor | dihydroergotamine mesylate | Injection, IV or nasal spray (Migranal) |
| Lidocaine | local anisthetic | 4.5%lidocaine | Nasal spray or drops | |
| Maxalt | vasoconstrictor | rizatriptan benzoate | 5mg, 10mg tablets | |
| Butalbital | sedative | |||
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Need More Imitrex? If you need more Imitrex than your insurance company will provide and your doctor is willing to prescribe, you can contact GlaxoSmithKline directly. They have a division called "Reimbursement Resource Center" (the name implies you have to pay up front, but that is not the case). Call them at 1-800-745-2967 option #3, give them the information they ask for, your doctor's name & number, insurance company info, etc. and they will assign you a case worker who will contact your insurance company and hopefully get them to increase the number of doses
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Stadol NS | synthetic opiod | butorphanol tartate | Also comes in injectible form. |
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Preventative Medications |
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| Verapamil | calcium-channel blocker | verapamil hydrochloride | tablets, blood pressure medication. | |
| Catapres | alpha-agonist | clonidine hydrochloride | tablets, blood pressure medication | |
| Lithium | anti-manic agent | lithium carbonate | Usually combined with verapamil or cortisone. Mainly for chronic clusters. Side effects. | |
| Depakote | seizure medication | divalproex sodium | tablets | |
| Neurontin | anticonvulsant | Gabapentin | ||
| Topamax | anitepileptic | topiramate | Side effects | |
| Methysergide (Sansert) | synthetic ergot / serotonin antagonist | methysergide | 2mg tablets. Side effects | |
| Indocin | NSAID | indomethacin | capsules, suppositories. Can be hard on stomach | |
| Bellergal S | vasoconstrictor / sedative | belladonna, ergotamine, phenobarbital | tablets | |
| Effexor | tricyclic antidepressant | venlafaxine hydrochloride | tablets | |
| Elavil | tricyclic antidepressant | amitriptyline | 10 - 150mg tablets | |
| Tegretol | anticonvulsant | carbamazepine | ||
| Lamictal | anticonvulsant | lamotrigine | ||
| Tenormin | beta-blocker | atenolol | ||
| Inderal | beta-blocker | propranolol | ||
| Amerge | vasoconstrictor | naratriptan hydrocloride | 1mg, 2.5mg tablets. Taken at bedtime, may prevent the night cluster. | |
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Transitional Medications |
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| Prednisone | steroid | prednisone | side effects likely | |
| Dexamethasone | adrenalcortical steroid | |||